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Drew Berry
Angiogenesis    |   Drew Berry
   

This animation shows the process by which tumors recruit new blood vessels thereby facilitating the metastatic behavior of stray cells that enter the circulation.

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Apoptosis    |   Drew Berry
   

This stunning Maya animation covers the death receptor signaling pathway that originates with binding of the Fas/TNF family of ligands, triggering of the caspase cascade, cytochrome C release from the mitochondria, apoptosome activation, and ensuing signal amplification.

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Replication    |   Drew Berry
   

Still one of the more complex and beautiful molecular animations ever made, this movie shows the components and dynamic processes involved in the replication of both the leading and lagging strands of DNA.

>> View the animation at WEHI
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CSF Receptor    |   Drew Berry
   

A molecular view of the surface of a stem cell highlighting the binding of G-CSF by its receptor, dimerization, signal transduction and the resulting effect on cell division and growth.

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Stem Cell Differentiation & Division    |   Drew Berry
   

An animation showing stem cell colonies expanding in the bone marrow. Some daughter cells differentiate intowhite blood cells and migrate into the blood, while others remain stem cells.

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Introduction to Transcription - part I    |   Drew Berry
   

Transcription factors assemble at a DNA promoter region found at the start of a gene. Promoter regions are characterised by the DNA's base sequence, which contains the repetition TATATA É and for this reason is known as the "TATA box".

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Introduction to Transcription - part II    |   Drew Berry
   

The RNA polymerase unzips a small portion of the DNA helix exposing the bases on each strand. One of the strands acts as a template for the synthesis of an RNA molecule. The base-sequence code is transcribed by matching these DNA bases with RNA subunits, forming a long RNA polymer chain.

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Golgi / ER Visualization    |   Drew Berry
   

A visualization of a cell's cytosplasm derived from electron tomography data from Brad Marsh's laboratory. The different components - nucleus, microtubules, mitochondria, ribosomes, smooth ER, rough ER, Golgi - are highlighted in separate 'passes' and then overaid as one. A great reminder of how crowded cellular interiors are!

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Translation    |   Drew Berry
   

Part 3 in Drew Berry's "Central Dogma" animations - the mRNA (yellow) is decoded inside the ribosome (purple and light blue) and translated into a chain of amino acids (red) as aminoacyl-tRNAs (green) deliver each amino-acid cargo (red/pink tip) to the ribosome.

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The Lifecycle of Malaria (Part 1)    |   Drew Berry
   

This animation represents part-1 of a 2-part series depicting the events of the malaria parasite lifecycle.
The parasite is shown entering the human host following a mosquito bite and we follow its progression initially to the liver and subsequently targeting erythrocytes on a large scale.

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The Lifecycle of Malaria (Part 2)    |   Drew Berry
   

Part 2 depicts events in the mosquito host.
The malaria parasite is shown reproducing in the mosquito's stomach followed by the development of cysts and infection of the salivary glands.

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Chromatin    |   Drew Berry
   

This animation shows the different levels of chromatin packing - starting with wrapping of DNA around histone octamers and nucleosome assembly, all the way to chromosome condensation during mitosis.

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DNA structure    |   Drew Berry
   

A series of short animations highlighting the structureand flexibility of the DNA double-helix.

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Restriction Endonuclease Digestion & Ligation    |   Drew Berry
   

This animation depicts the proces of DNA recombination. The DNA plasmid is first digested with the restriction endonuclease enzyme ecoRI. Then, a piece of DNA encoding a gene is inserted into the plasmid by DNA ligase.

>> View the animation at WEHI
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Sickle Cell Hemoglobin    |   Drew Berry
   

This animation depicts hemoglobin molecules binding to oxygen. The mutant form of hemoglobin is also shown and results in the assembly of the long stiff protein fibers characteristic of the disease sickle cell anemia.

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The Whole Brain Catalog    |   Drew Berry
   

A visualization of the possibilities of the Whole Brain Catalog (http://wholebraincatalog.org), an open source, multi-scale virtual catalog of the mouse brain.

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